Nyst M, Perriens J, Lusakumunu K, Kapita B, Piot P; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 238 (abstract no. Th.B.465).
Projet SIDA, Kinshasa, Zaire
METHODS: AIDS patients (pts) hospitalized in the internal medicine wards of Mama Yemo Hospital with oral and oesophageal candidiasis were randomized to receive gentian violet 0.5%, b.i.d. (G), or nystatin (N) 500.000 U q.i.d. mouth washes, or oral ketoconazole (K) 200 mg/d, until complete resolution of oral lesions and dysphagia. Pts treated with mouth washes swallowed their medication after mouth washing. Follow-up after 7 and 14 days included oral examination and microscopy of oral scrapings. Oesophagoscopy plus biopsy was repeated after 14 days therapy. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. None of the differences observed between treatments were significant. The overall mortality rate at 14 d was 35.1%, and 5 patients were lost to follow-up. CONCLUSIONS: The preliminary results of this study indicate that gentian violet may be as effective as ketoconazole or nystatin in oral candidiasis. However, oesophageal candidiasis was very resistant to treatment. Given its limited cost (less than 10% of that of K or N) G may become an interesting treatment alternative in our economic setting.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Candidiasis
- Candidiasis, Oral
- Deglutition Disorders
- Esophagitis
- Gentian Violet
- Humans
- Ketoconazole
- Mouthwashes
- Nystatin
- Prospective Studies
- therapy
Other ID:
UI: 102182044
From Meeting Abstracts