McNulty A, Bodsworth NJ, Radtke U, Rohrsheim R, Donovan B; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 294 (abstract no. PO-B02-0951).
Taylor Square Private Clinic, Sydney Hospital.
OBJECTIVES: To both characterise herpes zoster in HIV infection; and to assess its prognostic significance for the progression of HIV disease. METHODS: A cohort of 161 homosexual men with known time of HIV seroconversion (mean age 32 years) were recruited from the Sydney AIDS Prospective Study (SAPS) (n = 77) and a large private STD practice (n = 84). Case notes and SAPS assessments were reviewed for episodes of herpes zoster. Time from HIV seroconversion to AIDS and to death were compared using life tables analysis, as well as the CD4+ lymphocyte counts at 1, 2 and 3 years post HIV seroconversion, between those who developed zoster and those who did not. RESULTS: 33 cases of herpes zoster were experienced in a total of 30 (19%) subjects after a mean followup of 54 months. There was no anatomical clustering among first zoster episodes (4 involving cranial dermatomes; 4 cervical; 18 truncal; 2 sacral; 2 not specified). The median duration of rash was 15 days. Two required hospitalisation. The incidence of herpes zoster in the first year following seroconversion was 13 cases per 1000 person years; 43 in year 2; 74 in year 3; 93 in year 4; 15 in year 5; 21 in year 6; 78 in year 7. Comparable CD4+ lymphocyte counts were observed between those with and without zoster at 1 year (552 vs 574/cmm; p = 0.78), 2 years (432 vs 546; p = 0.049) and 3 years (435 vs 479; p = 0.54). Life table analysis revealed similar rates of progression to AIDS (p = 0.71) and to death (p = 0.51) for those who developed zoster and those who did not. CONCLUSION: Herpes zoster occurs commonly at all stages of HIV infection (overall incidence 45.4 episodes per 1000 person years). It does not appear to be associated with more rapid progression of HIV disease.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Disease Progression
- HIV Infections
- HIV Seropositivity
- Herpes Zoster
- Homosexuality
- Humans
- Incidence
- Male
- Prospective Studies
Other ID:
UI: 102203831
From Meeting Abstracts