Buckey JC, Lane LD, Gaffney FA, Watenpaugh DE, Levine BD, Wright SJ, Blomqvist CG.
ASGSB Bull. 1992 Oct; 6: 100.
University of Texas-Southwestern Medical Center, Dallas.
Experiment 294 on SLS-1 ("Cardiovascular Adaptation to Zero-Gravity", P.I.C. Gunnar Blomqvist) had three main goals. One: describe the early adaptation to microgravity using measurements of central venous pressure (CVP), heart rate and blood pressure. Two: understand postflight orthostatic intolerance by using differing stresses, e.g.: standing, lower body negative pressure, and autonomic agonist infusions. Three: demonstrate whether 6 degree head-down tilt (HDT)--a ground-based physiology model for 0-G--accurately mimics the cardiovascular effects of spaceflight. Three crewmembers were studied before, during and after both spaceflight and 24 hours of head-down tilt. An additional three crewmembers were studied with the stand test. CVP fell upon entering zero-gravity, disproving the hypothesis that CVP always increases with the zero-G induced headward fluid shift. All crewmembers had some degree of orthostatic intolerance. Heart rates were significantly higher with standing and stroke volume significantly lower. Early results show that head-down tilt does not accurately mimic the early adaptation to spaceflight. In conclusion, many traditional concepts describing the cardiovascular adaptation to space will need to be revised.
Publication Types:
Keywords:
- Acclimatization
- Blood Pressure
- Cardiovascular Physiology
- Central Venous Pressure
- Heart Rate
- Lower Body Negative Pressure
- Space Flight
- Stroke Volume
- Weightlessness
- Weightlessness Countermeasures
- Weightlessness Simulation
- NASA Discipline Cardiopulmonary
- NASA Discipline Number 00-00
- NASA Discipline Number 14-10
- NASA Program Flight
- NASA Program Space Physiology and Countermeasures
- Non-NASA Center
Other ID:
UI: 102212656
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