Keiser P, Jockus J, Horton H, Peterson D; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1994 Oct 4-7; 167.
University of Texas Southwestern Medical Center, Dallas, TX.
Corticosteroid treatment of AIDS related illnesses can theoretically potentiate other infections. A recent retrospective study suggested that the incidence of cytomegalovirus (CMV) retinitis increased after treatment with corticosteroids. Additionally, a prospective study of adjuntive corticosteroids therapy in pneumocystis carinii pneumonia had higher rates of active herpes simplex virus (HSV) infections in the treatment group. We performed a retrospective study to determine if there is an increased incidence of herpes viridae infections in AIDS patients treated with steroids. The case records of the Parkland Hospital AIDS Clinic were reviewed for patients treated with prednisone. Each case was matched with 3 controls by CD4 count. The number of active CMV, HSV and varicella-zoster infections (VZ) within 30 days of prednisone therapy were compared to the number of similar infections in the control group occurring within 30 days of the CD4 count used to match the control with the case. There were 211 cases and 633 controls. Average CD4 count was 101.5 for the cases and 97.9 for the controls (P=0.77). CMV infections were less frequent in patients treated with prednisone (cases=4, controls=46, P less than 0.001) while the incidence of HSV (cases=4, controls=9, P=0.63) and VZ (cases=1, controls=5, P=0.63) were similar in each group. We conclude that the use of prednisone is not associated with increased incidence of clinical herpes infections and is associated with a lower rate of active CMV infections in patients with AIDS.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Case-Control Studies
- Cytomegalovirus
- Cytomegalovirus Infections
- Herpesviridae Infections
- Humans
- Incidence
- Opportunistic Infections
- Prospective Studies
- Retrospective Studies
- Simplexvirus
- drug therapy
- therapy
Other ID:
UI: 102213816
From Meeting Abstracts