Brites C, Goyanna F, Franca L, Araujo AG, Harrington W, Badars C; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 323 (abstract no. Tu.B.2337).
Universidade Federal da Bahia (UFBA). Fax: (55 71) 245-7110.
Objective- To compare the clinical evolution of patients infected by the HIV-1, co-infected or not with HTLV-I/II. Methods- We reviewed the medical records of 137 HIV-1 - infected patients, followed at the UFBA's hospital, who had at least 6 months of clinical follow-up. We collected epidemiological, laboratorial and clinical data, including the frequency of opportunistic infections (OI) during the follow up period. Sera samples were tested for HTLV-I/II antibodies. The reviewers were blinded about the results of HTLV-I/II serology. Results- A total of 137 patients (81% male) were studied. Thirty patients (22%) were co-infected for: HTLV-I: 25 patients; HTLV-II: 4 patients; and, both viruses: 1 patient. The mean age (33.5 plus or minus 9.2 years) was similar, regardless gender or HTLV-I/II serology results. The mean time of follow up was 18.9 plus or minus 12.9 months. IVDU was the major risk for co-infection (p is less than 0.00001). By the time of diagnosis of HIV infection 79 (58%) patients already had AIDS. Patients co-infected by HTLV-I/II had an almost ten times higher frequency of strongyloidiasis, than those infected only by HIV-1 (p=0.029, Kruskal Wallis test), while diarrhea without an identified casual agent was more frequent among the HTLV-I/II seronegative patients (p=0.04). The levels of haemoglobin, CD4 and CD8, and absolute lymphocyte counts (ALC) were similar for both groups. Co-infected AIDS patients had higher means of CD4 (270 plus or minus 87 versus 151 plus or minus 177, p=0.03) and ALC (1540 plus or minus 770 versus 1007 plus or minus 636, p=0.01, Kruskal Wallis test). The outcome was similar regardless co-infection. Conclusion- In Bahia, Brazil, strongyloidiasis was significantly more frequent among the HIV-HTLV co-infected patients, than among those infected solely by the HIV. Also, AIDS patients harboring HTLV-I/II had a higher number of CD4+ cells and ALC. These data suggest that HIV-HTLV co-infection may modify the clinical picture of AIDS patients.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Brazil
- Communicable Diseases
- HIV
- HIV Infections
- HIV Seropositivity
- HIV Seroprevalence
- HIV-1
- HTLV-I Infections
- Health Personnel
- Human T-lymphotropic virus 1
- Human T-lymphotropic virus 2
- Humans
- Lymphocyte Count
- Male
Other ID:
UI: 102218438
From Meeting Abstracts