De Cock KM; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 4th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 4th 1997 Wash DC. 1997 Jan 22-26; 4th: 216 (abstract no. S20).
London School of Hygiene & Tropical Medicine, London, UK.
Of the 5-6 million people coinfected with HIV and Mycobacterium tuberculosis, the majority are residents of resource-poor countries, over three quarters in Africa, and an increasing proportion in South and South-East Asia. In heavily affected African countries increases in tuberculosis incidence in excess of 10% annually are occurring, and over half of new tuberculosis cases in such countries may be HIV-associated. Basic research is required for the development of new drugs and better vaccines, but so is operational research for better implementation of currently available interventions. Evaluation is required of innovative ways of providing diagnosis and treatment, including assessment of the optimal number of sputum smears to be examined, better assessment of smear-negative tuberculosis to exclude false positive diagnoses, examination of new diagnostic technologies, assessment of the frequency of tuberculosis in HIV-infected children, and alternative ways of providing directly observed therapy. Epidemiologic studies are needed to assess the importance of nosocomial transmission of M tuberculosis, to monitor the spread of drug resistance, and to study the importance of reactivation versus recent infection. Causes of the increased mortality in HIV-infected persons with tuberculosis require elucidation, to assess possibilities for prevention. The role of preventive therapy in HIV-infected persons in resource-poor countries requires further assessment. Strengthening of tuberculosis prevention and control is essential for improving the outlook for HIV-infected persons in developing countries.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Africa
- Asia, Southeastern
- Child
- Developing Countries
- Epidemiologic Studies
- HIV Infections
- HIV Seropositivity
- Health Resources
- Humans
- Incidence
- Infection
- Poverty
- Tuberculosis
- ethics
- therapy
Other ID:
UI: 102223056
From Meeting Abstracts