Pharo AN, Vergel N, Carroll E, Sauer L; National Conference on Women & HIV.
Natl Conf Women HIV Natl Conf Women HIV Innov Care Policy Prev 1997 Los Angel Calif. 1997 May 4-7; 107 (abstract no. 103.4).
New Concept Health Center, Houston, TX.
Objective: The primary objective is to evaluate the efficacy of two dosage levels, (10/20 mg/day), of oxandrolone in conjunction with resistance training and nutritional support for the treatment of weight loss and alterations in body composition characteristic of the Wasting syndrome in HIV positive women. Secondary objectives are to evaluate the effects of oxandrolone on HIV replication or AIDS progression as measured by CD4 counts, viral loads, and AIDS related events. Assessment of Karnofsky Performance status and Quality of Life were performed consistently throughout the study. Methods: Twenty female subjects were randomly assigned to one of two dosage groups. All patients are participating in a supervised resistance weight training program for at least one hour three times a week. All patients are provided with the same nutritional supplements including a Protein drink and multiple micronutrients, (including N-acetyl-cysteine, Flaxseed Oil, Fish Oils, multiple vitamin, antioxidants, vitamin C, etc.). Evaluation of nutritional status is performed at baseline and at the end of the study using Spectrocell Laboratory's EMA 2000 which includes an overall assessment of antioxidant status. Bioelectrical Impedance, (tetrapolar BIA, RJL Systems Fluid and Nutrition Analyzers), is used to evaluate body composition. Blood chemistries were performed to evaluate liver function, albumin, hormonal status, and immune status (CD4, CD8, and viral loads) at baseline, 2 months, and 4 months. The duration of the study is 16 weeks. Results: The study is still in progress, (week 7), but initial results demonstrate that oxandrolone has led to an increase in body weight, (av. 7.0 lbs.), increase in body cell mass, (av. 5.0 lbs.), increase in body fat, (av. 4.3 lbs.) and improved quality of life, (av. 50%). Initial nutritional assessment demonstrates a commonality of functional deficiencies in the B-vitamins and calcium. Antioxidant status was consistently average indicating a need for additional antioxidant supplementation. Data for the effect of oxandrolone on immune status and hormonal status is not available at this point. Final results of study will be available by the conference. Conclusions: Oxandrolone therapy demonstrates a significant increase in body weight in HIV positive women with no deleterious side effects. This increase in body weight reflects an increase in Lean body Mass and Fat Mass. Quality of life is significantly improved. Final results will demonstrate the effects of oxandrolone on body weight, body cell mass, fat mass, immune status, nutritional status, and quality of life.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antigua
- Body Composition
- Body Weight
- CD4 Lymphocyte Count
- Electric Impedance
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Nutrition Assessment
- Nutritional Status
- Oxandrolone
- Testosterone Congeners
- Viral Load
- Wasting Syndrome
- Weight Loss
Other ID:
UI: 102225788
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