Hagberg L, Andersson LM, Svennerholm B, Gisslen M; International Conference on AIDS.

Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. TuPeB3203.

L.Hagberg, University of Goteborg, Department of Infectious Diseases, 416 85 Goteborg, Sweden, Tel.: +46 31 343 42 24, E-mail: lars.hagberg@medfak.gu.se

HIV-1 RNA levels were longitudinally analysed in cerebrospinal fluid (CSF)and plasma in 10 antiretroviral naive HIV-1 patients before and after initiation of zidovudine (n = 9) or stavudine (n = 1) in combination with lamivudine and indinavir. Two patients discontinued the study after 16 and 18 months, one due to lipodystrophy and one refused further lumbar punctures. CSF HIV-1 RNAS decreased from in mean 3.8 log copies/ml to below 20 copies/ml in 8/9 patients after 4 months, in 7/9 after 14 months, in 7/7 after 24 months, and in 3/3 who have reached 36 months of follow up. In plasma, the mean HIV-1 RNA level decreased from 4.7 log copies/ml to below 20 copies/ml in 3/9 patients after 4 months, in 6/9 after 14 months, in 4/7 after24 months, and 1/3 after 36 months. Conclusion: Combination treatment with zidovudine/stavudine, lamuvidine, and indinavir has a long-term potent effect on CSF viral load in antiretroviral naive HIV-1 infected individuals.

Publication Types:

• Meeting Abstracts

Keywords:

• Combined Modality Therapy
• Electric Stimulation Therapy
• HIV-1
• Humans
• Indinavir
• Lamivudine
• Stavudine
• Viral Load
• Zidovudine
• cerebrospinal fluid
• organization & administration
• reverse transcriptase, Human immunodeficiency virus 1

Other ID:

• GWAIDS0001622

UI: 102239113

From Meeting Abstracts