TISSOT E, LIMAT S, CORNETTE C, JACQUET M, CAPELLIER G; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 612 (abstract no. 772).

Univ. Hosp., Besancon, FRANCE.

Catheter-Associated Urinary Tract Infection (CAUTI) is the third most frequent type of infection in Intensive Care Units (ICU). The incidence is higher than 15%. The aim of this prospective study was to determine the risk factors for CAUTI in a medical ICU. CAUTI is defined as a quantitative culture with >/= 10[5] microorganisms /ml. The following factors were studied : sex, age, severity score on admission (IGS2), length of stay in ICU, duration of catheterization, diabetes mellitus, prior antibiotic exposure during ICU hospitalization before CAUTI, immunodeficiency, neurologic disorders. These risks were measured by univariate and multivariate (logistic regression model) analyses (BMDP Statistical[TM] software). Each continous variable was changed into a dichotomic variable using the observed median. 149 consecutive patients were included : male/female ratio = 1.9; age = 56+/-18 years ; IGS2 score = 43+/-18 points; length of stay in ICU = 14+/-13 days; duration of catheterization = 15+/-13 days. CAUTI incidence was 29% and the most frequent isolated pathogens were Escherichi coli (34%), Pseudomonas sp. (16%), Enterococcus sp. (16%), Candida sp (14%) and negative coagulase Staphylococcus (6%). In univariate analysis, significant risk factors were : duration of catheterization [OR=5.7; CI[95]=2.4 - 13.3; p=0.00001], length of stay in ICU [OR=4.1; CI[95]=1.8 - 9.4; p=0.0003], and female sex [OR=3.0; CI[95]=1.4 - 6.5; p=0.006]. Prior antibiotic exposure appeared to be a protective factor [OR=0.19; CI[95]=0.08 - 0.4; p=0.00001]. In multivariate analysis, independent risk factors were : duration of catheterization [OR=19.4; CI[95]=5.5 - 68.7; p=0.0001] and female sex [OR=5.1; CI[95]=1.86 - 13.5; p=0.001]. Prior ATB exposure was a significant protective factor [OR=0.06; CI[95]=0.19 - 0.21; p=0.0001]. These results suggest that the length of catheterization and female sexe increase risk of CAUTI and are in agreement with other studies. Prior antibiotic exposure during ICU hospitalization decreases this risk.

Publication Types:

• Meeting Abstracts

Keywords:

• Anti-Bacterial Agents
• Catheterization
• Female
• Humans
• Incidence
• Infection
• Infection Control
• Intensive Care Units
• Logistic Models
• Male
• Prospective Studies
• Risk Factors
• Urinary Tract Infections

Other ID:

• GWAIDS0008741

UI: 102246238

From Meeting Abstracts