Agurto H, Lama J, Seas C, Bussalleu A, Samalvides F, De los Santos V, Gotuzzo E; IAS Conference on HIV Pathogenesis and Treatment (2nd : 2003 : Paris, France).

Antivir Ther. 2003; 8 (Suppl.1): abstract no. 1203.

Hospital Nacional Cayetano Heredia

Nutritional deficiencies play an adverse role in HIV-infected patients contributing to the infection pathogenesis and immunological system weakening. These deficiencies have not been well characterized in patients from developing countries, where access to antiretroviral therapy is highly restricted. To gain further insight into HIV-infected patients' nutritional status in these settings, we conducted a cross-sectional anthropometric, haematological, biochemical and body composition (using bioelectrical impedance analysis) assessment that compared HIV-infected patients and healthy controls in Lima, Peru. Naive ambulatory patients with and without HIV-related wasting syndrome (33 in each group) were paired 1:1 with healthy controls, matched by age (+/-5 years), sex and socio-economical level. Wasting patients have lower lean body mass (44.81 +/-8.24 vs 55.52 +/-10.17 kg), fat body mass (11.31 +/-4.34 vs 16.63 +/-4.77 kg) and phase angle alpha - an indirect measurement of intracellular water volume (6.09 +/-1.08 vs 7.47 +/-0.81); as well as higher extra cellular mass to body cell mass ratio (1.13 +/-0.13 vs 0.97 +/-0.08) than their controls (P<0.0001 for each comparison). Triceps skin-fold thickness and mid-arm circumference were also lower in these patients. Measurements of serum albumin (3.83 +/-0.43 vs 4.26 +/-0.21 g/dl), serum total cholesterol (129.3 +/-30.82 vs 177.82 +/-32.89 mg/dl), WBC count (5355 +/-1734 vs 8330 +/-2217 cells/micro-l) and absolute lymphocyte count (1603 +/-1016 vs 2487 +/-668 cells/micro-l) also showed a marked decrease in wasting patients (P<0.0001 for each comparison). However, in non-wasting patients just differences in WBC count (5662 +/-1981 vs 7013 +/-1661 cells/micro-l) and serum total cholesterol (140.59 +/-31.26 vs 178.65 +/-33.77 mg/dl) were found (P<0.001 for both comparisons). HIV-related wasting syndrome is associated with lower lean body mass, fat body mass and intracellular water volume. Future studies should determine when nutritional changes began in HIV-infected patients and nutritional interventions should be tested in attempt to prevent further impairment.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Animals
• Body Composition
• Cadherins
• Case-Control Studies
• Electric Impedance
• Fats
• HIV Infections
• HIV Seropositivity
• HIV Wasting Syndrome
• Humans
• Nutritional Status
• Peru
• Water
• immunology

Other ID:

• GWAIDS0023852

UI: 102263476

From Meeting Abstracts