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Incidence of Penicillin, Doxycycline, Macrolide and Fluoroquinolone Resistant Streptococcus pneumoniae (SPN) in Canada: Results of the Canadian Respiratory Organism Susceptibility Study (CROSS), 1997-2002.

BELLYOU T, PALATNICK L, RIMMER E, NICHOL K, ZHANEL GG, HOBAN DJ; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. C2-1633.

Health Sciences Centre and University of Manitoba, Winnipeg, MB, Canada

BACKGROUND: Ongoing surveillance is the principle mechanism for understanding evolving antibiotic resistance in SPN. Penicillin (Pen), doxycycline (Doxy), macrolide (Mac) and fluoroquinolone (FQ) resistance in SPN is a global issue. The purpose of this annual, multi-year, national, standardized surveillance study was to assess the potential for resistance in Canadian respiratory isolates of SPN. METHODS: 25 medical centres representing 9 of 10 Canadian provinces submitted up to 100 consecutive respiratory tract isolates of SPN each year to a coordinating reference laboratory (Health Sciences Centre, Winnipeg, Manitoba). Susceptibility testing against 25 antibiotics was performed by the NCCLS-approved broth microdilution method. Antibiotic prescription (Rx) data was obtained from IMS Health Canada. RESULTS: The incidence of Pen, Doxy, Mac (Clarithromycin) and FQ (Ciprofloxacin) resistance in SPN over the past 5 years is shown below: Overall, antibiotic Rx decreased by 13.1% from 1996 to 2001. beta-lactam and tetracycline Rx decreased by 24.1 and 24.9%, respectively, while macrolide and FQ Rx increased by 10.0 and 72.8%, respectively, during this study period. CONCLUSIONS: The incidence of Pen-resistant SPN in Canada increased from 6.4% in 1997/98 to 13.8% in 2001/02 despite reductions in beta-lactam Rx. Doxy resistance decreased along with Doxy Rx. Mac and FQ resistance is stable despite large increases in Rx.

Publication Types:
  • Meeting Abstracts
Keywords:
  • Amoxicillin
  • Anti-Bacterial Agents
  • Canada
  • Ciprofloxacin
  • Disease Susceptibility
  • Doxycycline
  • Fluoroquinolones
  • Incidence
  • Manitoba
  • Penicillins
  • Streptococcus pneumoniae
Other ID:
  • GWAIDS0028618
UI: 102268242

From Meeting Abstracts




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