DOTEVALL L, BORG R, HAGBERG L; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. L-2167.
Dept of Infectious Dis, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden
BACKGROUND: Cerebrospinal fluid (CSF) findings and clinical efficacy of oral doxycycline were studied in patients with nervous system manifestations of tick-borne B burgdorferi sp infections. METHODS: CSF examinations and clinical evaluations were done before and 6-8 weeks after doxycycline treatment of 69 adult patients with Lyme neuroborreliosis (age 19-79 yrs; median 56). Lymphocytic meningitis was found in all patients and 94% had radiculitic pain. Uni- or bilateral facial palsy was noted in 41% and other pareses were found in 12% of the patients. Durations of the doxycycline treatment given only by oral route were 10-17 days (median 10 days). CSF were examined for cell counts, cytology, protein concentrations, albumin indices, protein electrophoresis, immunoglobulin concentrations, and antibody reactions to B borgdorferi sp. These data were compared with clinical findings of the patients. RESULTS: CSF cell counts before treatment were 6-1110 x 106/L (median 120), and 6-8 weeks after doxycycline treatment 1-45 x 106/L (median 8). CSF protein concentrations before treatment were 260-4800 mg/L (median 1040), and after treatment 149-1040 mg/L (median 444). All patients were found to be clinically improved after doxycycline treatment and no patients relapsed over a six months period. CONCLUSION: The CSF findings support the clinical evaluation of a short course of oral doxycycline treatment as an effective therapy for Lyme neuroborreliosis.
Publication Types:
Keywords:
- Adult
- Doxycycline
- Facial Paralysis
- Follow-Up Studies
- Humans
- Immunoglobulins
- Lyme Neuroborreliosis
- cerebrospinal fluid
- therapy
Other ID:
UI: 102269517
From Meeting Abstracts