Brettle RP, Jones GA, Bingham J, Spacey BE, Weatherley B, Churchus R; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 203 (abstract no. W.B.O.3).
I.D.U., City Hospital, Edinburgh, Scotland
OBJECTIVE: A pharmacokinetic trial of zidovudine in injection drug use (IDU) related HIV. METHODS: 6 males and 6 females, with a mean age of 26.5 years (22-39) were treated with zidovudine. They appeared to have discontinued IDU but were currently using orally or by inhalation cannabis, benzodiazepines, methadone, and/or dihydrocodeine. They spent the first week in hospital on 250 mgm. zidovudine 6 hourly. Three sampling periods of 6 hours over 14 days occurred to determine the pharmacokinetics of zidovudine. RESULTS: Differences in the pharmacokinetics of AZT were observed for all parameters in the 10 patients on oral opiates, benzodiazepines or cannabis (Gp I) compared to the two patients taking only cannabis and/or benzodiazepines (Gp II) and reported normal values (Gp III). TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSION: Oral opiates and benzodiazepines alters the pharmacokinetics of zidovudine. The mechanism is as yet unknown and therefore further studies are required.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Benzodiazepines
- Cannabis
- Female
- HIV
- HIV Infections
- HIV Seropositivity
- Humans
- Idoxuridine
- Male
- Methadone
- Narcotics
- Substance-Related Disorders
- Zidovudine
- pharmacokinetics
Other ID:
UI: 102176749
From Meeting Abstracts