Leoncini F, Carbonai S, D'Elia D, Paladini A, Stefanelli S, Dionisio D; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 231 (abstract no. M.B.2199).
Infectious Disease Departments of Prato
Cryptosporidium enteritis (CE) represents a major problem for AIDS patients. Up to date many therapeutic agents have been tried but no treatment proved to be effective and safe. Here we report the successful treatment with the antifungal drug fluconazole in 4 AIDS patients. Our first observation regards a 34-year old homosexual man who presented a severe CE resistant to spyramicin treatment and oral candidiasis. Oral fluconazole treatment for oral candidiasis was followed by the improvement of CE and disappearance of Cryptosporidium oocysts in stools (examination with Ziehl-Neilsen strain, modified by Henriksson). The following relapses of CE were favourably affected by fluconazole treatment. On the basis of this observation, we treated 3 other patients affected by CE in AIDS with fluconazole, obtaining the clinical improvement in all cases with disappearance of oocysts in stools in one case and a marked decrease in their number in the others. Therefore our observation supports the hypothesis that fluconazole is an useful therapeutic tool for the control of CE in AIDS.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antifungal Agents
- Candidiasis, Oral
- Enteritis
- Fluconazole
- Humans
- Male
- therapy
Other ID:
UI: 102183121
From Meeting Abstracts