Baldo-Correa E, Fonseca ME, Cunha JM, Moco MR, De Bonis M, Busin CF; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 46 (abstract no. W.B.92).
Federal University of Rio de Janeiro, RJ, Brazil
OBJECTIVE: To evaluate jejunal structural changes related to HIV. METHODS: Ten HIV-infected male patients (9 at stage IV and 1 at stage II according to the 1986 CDC classification) and 3 healthy controls were submitted to jejunal biopsy. Specimens were glutaraldehyde/osmium fixed, dehydrated, embedded in resin and examined by electron microscopy after lead citrate/uranyl acetate staining of sections. RESULTS: Intense SER proliferation in enterocytes, microvillous changes, vacuolization and lymphocytic infiltration were seen in the epithelium. Striking vascular lesions appeared at the endothelial level where varying degrees of hypertrophy with edema, mitochondrial degeneration and RER dilation were the main features. There was an evident correlation between the "sausage"-form crystalloid structures observed in endothelial cell cytoplasm, strongly suggestive of peroxisomes, and its active state. Inflammatory infiltration of lamina propria with plasma cells, macrophages and eosinophils, with occasional evidence of viral particles in abnormal lymphocytes were also seen. These particles were ultrastructurally interpreted as HIV particles. The findings above were not seen in the 3 controls. CONCLUSIONS: We emphasize the numerous peroxisomes in endothelial cells and the ultrastructural identification of HIV particles in jejunum, findings not previously reported. The other non-specific features are consistent with those described in literature.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Biopsy
- Centers for Disease Control and Prevention (U.S.)
- HIV Infections
- HIV Seropositivity
- Humans
- Jejunum
- Male
- Microscopy, Electron
- United States
Other ID:
UI: 102192138
From Meeting Abstracts