Grant MD, Smaill FM, Rosenthal KL; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 29 (abstract no. WS-A13-3).
Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario.
We and others have previously shown that HIV-infected individuals possess CD8+ CTL) which lyse activated uninfected CD4+ lymphocytes. These CTL are TCR ab+, but not MHC-restricted. They can be stimulated with Con A or HIV, but are not stimulated by EBV. These CTL do not lyse activated CD8+ lymphocytes or EBV-transformed B lymphocytes. Cytolytic activity is often greater against CD4+ lymphocytes from uninfected individuals than against autologous CD4+ lymphocytes, suggesting that autologous targets of the CTL are eliminated in vivo. In some HIV-infected individuals, CTL activity against autologous CD4+ lymphocytes decreased or disappeared coincident with a fall in CD4+ lymphocyte counts, whereas CTL activity against CD4+ lymphocytes from an uninfected individual was maintained. HIV-infected individuals with Con A inducible CTL activity against autologous CD4+ lymphocytes had a significantly greater loss of CD4+ lymphocytes over a 6 month followup period than HIV-infected individuals who did not have CTL activity against autologous CD4+ lymphocytes (p < .01). The mean (+/- SD) fall in CD4+ lymphocyte counts in 7 HIV-infected individuals with CTL activity against autologous CD4+ lymphocytes was 121 +/- 84 or 36% over 6 months as compared to no significant change in mean CD4+ lymphocyte counts in 7 HIV-infected individuals without CTL activity against autologous CD4+ lymphocytes. These results suggest that CTL activity against autologous CD4+ lymphocytes may play a role in CD4+ lymphocyte depletion in HIV infection.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- Antigens, CD8
- CD4 Lymphocyte Count
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- HIV
- HIV Antigens
- HIV Infections
- HIV Seropositivity
- Herpesvirus 4, Human
- Lymphocyte Depletion
- Receptors, Antigen, T-Cell
- T-Lymphocytes, Cytotoxic
- immunology
Other ID:
UI: 102203801
From Meeting Abstracts