Brossard G, Bioulac-Sage P, Pellegrin JL, Leng B; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 406 (abstract no. PO-B13-1625).
CHR Villeneuve sur lot, France.
The development of cutaneous T-cell lymphome (CTCL) is unusual in individuals with human immunodeficiency virus type 1 (HIV1) with only six published cases. We present a another case. REPORT OF CASE: A 39 years old white man was found to be HIV+ en 1991. Analysis of T cell markers an peripheral blood lymphocytes showed an absolute++ CD4+ cell count of 82/microliters and CD8+ cell count of 193/microliters. The medical history included chronic hepatitis C infection. For this co-infection oral zidovudine and subcutaneous interferon alfa therapy was begun. After six months a pruritic, exfoliating erythroderma developed with hepatomegaly and alopecia. Results of laboratory evaluation revealed a white blood cell count of 1.3 x 10/l with an absolute CD4+ cell count of 4/microliters asparate aminotransferase was normal. A series of biopsy specimens showed a lymphoid cell infiltrate. Immunohistochemical staining revealed that the lymphoid cells was CD3+, CD4+, CD8-. Few cells was CD30+. HTVL1 was negative. Computed tomographic scans revealed only a mild hepatomegaly. Hepatic biopsy showed fibrosis with chronic hepatitis C. Bone biopsy was normal. Interferon alpha was stopped and electrontherapy was begun. DISCUSSION: Only one case of AIDS associated non Hodgkin's lymphoma that appeared have arisen from a T lymphocyte containing integrate HIV1 was reported. In our study we wait the result of molecular analysis to prove the role of HIV1 as a transforming agent.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- CD8-Positive T-Lymphocytes
- Dermatitis, Exfoliative
- HIV Infections
- HIV Seropositivity
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Lymphocytes
- Lymphoma, T-Cell
- Lymphoma, T-Cell, Cutaneous
- Male
- Skin Neoplasms
- T-Lymphocytes
Other ID:
UI: 102204569
From Meeting Abstracts