Gold J, High H, Li Y, Michelmore H, Bodsworth N, Finlayson R, Furner V, Allen B, Oliver C; Australasian Society for HIV Medicine. Conference.
Annu Conf Australas Soc HIV Med. 1996 Nov 14-17; 8: 70 (abstract no. 62).
Generalised wasting and loss of lean body mass are common problems that affect the survival, quality of life and self image of patients who have HIV infection. The causes of nutritional abnormalities in patients with middle and late stage HIV disease are multifactorial and include decreased intake, increased requirements, decreased assimilation due to maldigestion or malabsorption, metabolic or endocrine abnormalities or increased excretion. It is essential that all patients who present with weight loss are investigated, and underlying infections are treated. However, there will remain a significant proportion of patients for whom nutritional problems will require specific therapeutic intervention. Various agents have been used in an effort to improve body composition, but they tend to increase fat and body water without having an effect on lean body mass. These agents are usually expensive and have wide-ranging side effects, as well as requiring patients to take many additional tablets each day. Over the past five years, the Albion Street Centre has investigated the use of the anabolic steroid, nandrolone decanoate, in patients who have moderate weight loss that is unresponsive to dietary management alone. Our experience indicates that two weekly injections of 100mg of nandrolone decanoate significantly improves lean body mass, weight and quality of life without causing adverse reactions and at a relatively low cost. More recently, our research indicates that patients who receive structured nutritional intervention, including nandrolone decanoate, may have an improved survival rate after an AIDS diagnosis. This may be related to the increase in lean body mass and improvement in quality of life that could provide patients with a better response capacity to hospitalisation and treatment. This presentation will cover a broad overview of the role of nutritional status in HIV disease, focusing on the treatment options available and detailing our clinical experience with nandrolone decanoate in patients who have moderate to severe wasting.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Body Composition
- Body Weight
- Drug Therapy, Combination
- HIV Infections
- HIV Seropositivity
- Humans
- Nandrolone
- Nutritional Status
- Weight Loss
- drug therapy
- nandrolone decanoate
- therapy
Other ID:
UI: 102221897
From Meeting Abstracts