BLEKHER L, SIEGMAN-IGRA Y, SCHWARTZ D, BERGER S, CARMELI Y; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 619 (abstract no. 1432).

Tel Aviv Med. Ctr., Tel Aviv, ISRAEL.

Leminorella spp. (Lm), a Gram negative bacillus belonging to the enterobacteriaceae was first described as enteric group 57 in 1981. Lm was isolated from feces and urine specimens but clinical correlates were not studied. The purpose of this study was to investigate the clinical significance and spectrum of Lm infection, as well as the antibiotic susceptibility pattern of this organism. The microbiology laboratory log was searched for isolation of Lm from clinical specimens, and the medical records were reviewed retrospectively. Identification of organism was done by an automated system (Baxter/Microscan). 18 cases were identified during the period 1/97-4/99, and 12 cases were reviewed. 11/ 12 isolates were nosocomial. There was no clustering of cases in time or space. Mean age was 57 (range 10-88), 75% were male, 10/12 had underlying conditions that may have predisposed them to the infection. 7/12 patients had fever, 6 leukocytosis and 1 leukopenia at the time Lm was isolated. The site of isolation was urine in 6, wound in 3, and blood, peritoneal fluid, and sputum in 1 each. Lm was the only isolate from the site of infection in 7 cases. Based on clinical data Lm was classified as a definite pathogen in 6 cases, probable in 2, and a possible pathogen in 3; causing UTI in 5 patients, surgical site infection in 2, bronchitis, soft tissue infection, primary bacteremia and secondary peritonitis in 1 each. Only in one case did Lm isolate have no clinical significance. All 12 isolates were resistant to second gen. cephalosporins. 5/12 isolates were susceptible to penicillins, third gen. cephalosporins and ciprofloxacin. 7/12 of isolates were resistant to penicillins, penicillin/inhibitor combinations, and to cefotaxime. 11/12 isolates were susceptible to ceftazidim, and all were susceptible to imipenem and amikacin. We conclude that Leminorella spp. should be considered as a significant nosocomial pathogen capable of causing a variety of clinical syndromes. Clinical isolates of Leminorella are often resistant to multiple antibiotic agents.

Publication Types:

• Meeting Abstracts

Keywords:

• Amikacin
• Anti-Bacterial Agents
• Bacteremia
• Bacteria
• Cephalosporins
• Ciprofloxacin
• Enterobacteriaceae
• Enterobacteriaceae Infections
• Gram-Negative Bacteria
• Humans
• Imipenem
• Male
• Penicillins
• Piperacillin
• Urinary Tract Infections

Other ID:

• GWAIDS0008683

UI: 102246180

From Meeting Abstracts