Groll A, Petraitis V, Petraitiene R, Field-Ridley A, Candelario M, Mickiene D, Piscitelli S, Walsh T; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 582 (abstract no. 2006).

NIH, Bethesda, MD, USA

The activity of multilamellar liposomal nystatin (Nyotran[TM]) against subacute disseminated candidiasis was investigated in persistently neutropenic rabbits. Antifungal therapy was administered for 10 days starting 24 hours after intravenous inoculation with 1 x 10[3] blastoconidia of C. albicans. Responses to treatment were assessed by the quantitative clearance of the organism from tissues. Treatment groups [n = 8 animals each] consisted of liposomal nystatis administered at 2 and 4 mg/kg QD (LNys2, LNys4), amphotericin B deoxycholate at 1 mg/kg QD (DamB), and fluconazole at 10 mg/kg QD (Flu). [table: see text]. Treatment with LNys2 and LNys4, DamB and Flu resulted in a similar significant clearance of C. albicans from tissues. When the proportion of animals infected at least at one of the 5 studied tissue sites was analyzed, a dose-dependent response to treatment with liposomal nystatin was observed (p0.05). As compared to DamB treated animals, mean serum creatinine and blood urea nitrogen levels at end of treatment were significantly lower in animals treated with either 2 or 4 mg/kg/day of liposomal nystatin (p0.01 for all comparisons). In summary, liposomal nystatin was less nephrotoxic than amphotericin B and had comparable, dose-dependent activity in the early treatment of subacute disseminated candidiasis in persistently neutropenic rabbits.

Publication Types:

• Meeting Abstracts

Keywords:

• Amphotericin B
• Animals
• Blood Urea Nitrogen
• Candidiasis
• Deoxycholic Acid
• Fluconazole
• Liposomes
• Nystatin
• Rabbits
• amphotericin B-deoxycholate

Other ID:

• GWAIDS0009289

UI: 102246787

From Meeting Abstracts