Dantas MC, Lima JN, Vitoria MA, Teixeira PR, Costa-Filho RB, Grangeiro AL; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. B10188.
STD/AIDS Program - Ministry of Health (MOH), Brasilia, Brazil
ISSUES: PLWA in Brazil have been an universal access to ART since 96 and 113000 HIV+ individuals was on treatment in the Public Health System in Dec. 2001. However, as have been occurred in developed countries, the wide use of the ART promotes the emergence of HIV resistant strains that can commits the effectiveness of ART. Considering the impact that this aspect can bring up to Brazilian HIV treatment policy, the MOH decided to to establish a National Network of Genotyping Test (RENAGENO) enabled to perform and interpret the results of HIV-1 resistance tests using an adequate and rational criteria. DESCRIPTION: For the initial accomplishment of the RENAGENO study, 12 laboratories was initially accredited and 60 reference genotyping physicians (MRG) from different parts of the country was trained to assist the demand in an regional basis. MRG will analyze the requested genotyping test as established in protocol entry criteria, authorize the test and clinically interpret the test result, suggesting new schemes or therapeutic options to the assistant physician based on this interpretation. In order to assist the initial test demand, MOH has acquired 6000 genotyping tests which will be used in HIV+ patients in 1st. therapeutic failure with ARV schemes that contains at least one PI and at least one recent viral load measurement over 5000 cp/ml. LESSONS LEARNED: Considering the high level of complexity of this kind of test, costs and high number of patients on ART in Brazil, it is important to know the training and capacity needs to best qualify professionals from laboratory and clinical areas, guaranteeing an adequate use of these tests. RECOMMENDATIONS: The decision making to use of high tech and costly laboratory methodologies for diagnosis and monitoring HIV patients should be considered by a fine and rational analysis of the social, economic and health infrastructure conditions of the country and can be establish even in countries with limited economic resources.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Brazil
- HIV
- HIV Infections
- HIV Protease
- HIV Seropositivity
- HIV-1
- Humans
- Laboratories
- Laboratory Techniques and Procedures
- reverse transcriptase, Human immunodeficiency virus 1
Other ID:
UI: 102256096
From Meeting Abstracts