BARTON T, GHAFFAR F, MCCRACKEN GH; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. G-140.

University of Texas Southwestern Medical Center, Dallas, TX

Background. There is interest in whether widespread use of PCV7 will affect the incidence of IPD in children and the emergence of infections caused by non-vaccine-type strains (NVT). Methods. Isolates of SP from patients with IPD from Jan. 1999 to Mar. 2002 were collected at Children's Medical Center of Dallas. The medical charts were reviewed for diagnosis, outcome and history of receiving PCV7. Serotyping was performed on these isolates using specific pneumococcal antisera. Results. To date, all cases from 1/99 to 3/02 have been fully reviewed, and the cases from 1997 to 1998 have been screened. Vaccination with PCV7 was implemented in 9/00. In 1997, there were 51 cases of IPD, 60 in 1998, 75 in 1999, 76 in 2000, 67 in 2001, and 13 in the first 3 months of 2002. The number of inpatient and outpatient visits per year increased 30% from 219,537 to 285,477 from 1997 to 2001. The frequency of IPD was constant ranging from 0.23 to 0.28/1000 visits. The peak number of cases occurred from September to March of each year. There were 70 cases in the peak season from 9/00 to 3/01 (10 cases/mo), whereas from 9/01 to 3/02 there were 29 cases (4.1/mo). This difference was statistically significant, as it was also for the peak seasons from 1998 to 2000. From 9/01 to 3/02, 14/29 (47%) of isolates were vaccine-type (VT), compared to 76/112 (68%) of isolates from the earlier peak periods (p=0.054). Immunization history and serotype data were available for 76 patients since PCV7 implementation in 9/00. There were 16 cases in patients who had received one or more doses of PCV7, and 5 (31%) had an infection with VT-SP. None of these 5 were fully vaccinated. By contrast, 38/76 (63%) of unvaccinated children were infected with VT-SP (p=0.044). Conclusions. Although the annual incidence of IPD in our hospital has remained stable through 2001, there was a significant decrease in the number of cases seen per month in the most recent winter season, along with a trend to a decreasing proportion of VT strains.

Publication Types:

• Meeting Abstracts

Keywords:

• Child
• Humans
• Immune Sera
• Incidence
• Infant
• Pneumococcal Vaccines
• Serotyping
• Streptococcus pneumoniae
• Vaccination
• methods
• supply & distribution

Other ID:

• GWAIDS0028732

UI: 102268364

From Meeting Abstracts