Fabricius EM; International Conference on AIDS.

Int Conf AIDS. 1989 Jun 4-9; 5: 230 (abstract no. M.B.P.52).

Augenklinik des Krankenhauses Harlaching, Munich, FRG

OBJECTIVE: To prove whether Acyclovir long term therapy is necessary to prevent relapses of Acute Retinal Necrosis Syndrome (ARN) caused by Herpes simplex Virus (HSV) or Varicella Zoster Virus (VZV) as opportunistic ocular infection. METHODS: Retrospective report on 4 patients with ARN. 3 had got Acyclovir therapy for extraocular herpetic infections over a limited period before, one received Acyclovir initially for treatment of ARN and HSV encephalitis (1500 mg/d intravenously), followed by long term therapy (800 mg/d per os) over a 7 months follow up period. RESULTS: In the 3 cases with extraocular diseases ARN occurred several weeks after suspension of Acyclovir therapy causing rapid visual damage. In one case initial Acyclovir therapy provided resolving of ARN and cerebral symptoms, maintenance therapy has prevented relapses for 7 months. CONCLUSION: ARN should be an indication for long term therapy with Acyclovir to prevent blindness in AIDS patients.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Acyclovir
• Drug Therapy, Combination
• Herpesvirus 3, Human
• Humans
• Opportunistic Infections
• Retinal Necrosis Syndrome, Acute
• Simplexvirus
• drug therapy
• therapy

Other ID:

• 00101589

UI: 102176905

From Meeting Abstracts