Solinger AM, Hoppenjans WB, Orme R, Bibler M; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 251 (abstract no. M.B.P.178).
University of Cincinnati Medical Center, Cincinnati, Ohio. USA
Unusual infectious disease as well as unusual presentations of common infectious diseases have frequently been reported in patients with AIDS. We report two cases of an unusual presentation of a verrucous hyperkeratotic type of disseminated Herpes zoster in adult males with AIDS. We feel that this presentation represents an extreme of the V-Z infection not previously reported. These hyperkeratotic, crusted skin nodules developed after the generalization of typical herpes zoster and progressed despite oral and intravenous acyclovir. Both patients had secondary Candida albicans infections of the crusted lesions and evidence of atypical Mycobacterial infection. One patient had cultures of blood and skin positive for Mycobacterium avium-intracellulare. Of interest, both patients ultimately developed a vacuolar myelopathy (confirmed by clinical presentation and EMG). We believe that our patients represent a presentation of disseminated Herpes zoster unique to the AIDS patient that will be encountered more frequently in the future. The unrelenting, disfiguring nature of this disease as well as its apparent unresponsiveness to Acyclovir is of particular concern. One of the patients succumbed to his myelopathy while the other developed it during a worsening of his skin lesions. This clinical picture may be a harbinger of a rapidly fatal outcome.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Acyclovir
- Adult
- Communicable Diseases
- Herpes Zoster
- Herpesvirus 3, Human
- Humans
- Male
- Mycobacterium avium Complex
- Mycobacterium avium-intracellulare Infection
- Skin
- Skin Diseases
- organization & administration
Other ID:
UI: 102177032
From Meeting Abstracts