Sanusi S, Olopoenia L, Grigsby M, Barnes S, Afessa B, Frederick W; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 261 (abstract no. M.B.P.238).
Howard University Hospital, Washington, DC, USA
OBJECTIVE: To determine the prevalence of enteric protozoa in symptomatic and asymptomatic adult HIV-1 seropositive patients. It has been suggested that protozoan parasites may play a role in the progression of HIV-1 infection. METHODS: Stools from 64 adult (46 males; 18 females) HIV-1 seropositive patients enrolled in a study of the natural history of AIDS were analyzed for the presence of enteric protozoa. The MIF and trichrome staining procedures for protozoa and the modified acid fast Kinyoun stain for Cryptosporidium were performed on freshly collected stool samples preserved in 10% formalin. RESULTS: Mean age of group was 35.4 years. Risk factors for HIV-1 included homosexuality in 32 patients, intravenous drug use (IVDU) in 27 and heterosexual contact in 5. Twenty patients had AIDS, 27 had ARC and 17 had generalized lymphadenopathy (GLN). Twenty-eight (43.8%) patients had diarrhea. Overall 21/64 (32.8%) patients had evidence of enteric protozoa in their stools; 4 symptomatic and 3 asymptomatic AIDS patients, 9 symptomatic and 3 asymptomatic ARC patients and 2 symptomatic GLN patients. Among patients with diarrhea E.nana (12) and B.hominis (6) were the predominant protozoa seen. No cases of cryptosporidium, enteric bacterial or fungal pathogens were isolated. CONCLUSIONS: No significant differences were noted between homosexual and IVDU patients or between AIDS and ARC patients in the frequency of enteric protozoa seen. Symptomatic ARC patients were found to be infected more frequently with protozoan parasites. E.nana and B.hominis were the most frequent protozoa identified in symptomatic patients and should be considered as additional protozoan pathogens causing diarrhea in symptomatic HIV-1 patients.
Publication Types:
Keywords:
- AIDS-Related Complex
- Acquired Immunodeficiency Syndrome
- Adult
- Animals
- Blastocystis Infections
- Diarrhea
- Endolimax
- Female
- HIV Infections
- HIV-1
- Homosexuality
- Humans
- Male
- Parasites
- Prevalence
- parasitology
Other ID:
UI: 102177092
From Meeting Abstracts