Bosson D, Bril T, Harnie S, Dewit S, Clumeck N; International Conference on AIDS.

Int Conf AIDS. 1989 Jun 4-9; 5: 267 (abstract no. M.B.P.271).

Free University of Brussels, Brussels, Belgium

OBJECTIVE: Hyporeninemic hypoaldosteronism, associated with HIV-1 infection has been reported (F. Kalin '87). In order to evaluate the occurrence of this anomaly we set up a prospective study. METHODS: We measured plasma cortisol (F), aldosterone (Aldo) and renin activity (PRA) by specific radioimmunoassay as well as plasma and urinary ionogram in 217 HIV-1 infected caucasians (CDC stage 2 to 4). Control population was comparable for sex, age, and sodium dietary content. Statistical analysis was performed using Mann-Whitney test and multivariate analysis. TABULAR DATA, SEE ABSTRACT VOLUME. RESULTS: F was significantly higher in patients than in controls (p less than 0,05). Aldo and PRA were significantly lower in HIV-1 infected patients (p less than 0,001). Neither of the parameters varied according to stage. Three patients presented a hyporeninemic hypoaldosteronism with persistent hyperkalemia. CONCLUSION: Hyporeninemic hypoaldosteronism with intact glucocorticoid secretion in HIV-1-infection suggests a dysfunction of the juxtaglomerular apparatus rather than a primary adrenal damage (J. Glasgow, '85). The early presence of these features (stage 2) rules out any causal effect of opportunistic infections (stage 4) (L. Membreno '87), but suggests a direct effect of the virus or an auto-immune etiology.

Publication Types:

• Meeting Abstracts

Keywords:

• Aldosterone
• HIV Infections
• HIV Seropositivity
• Hormones
• Humans
• Hyperkalemia
• Hypoaldosteronism
• Prospective Studies

Other ID:

• 00123489

UI: 102177125

From Meeting Abstracts