Causey DM, Rao NA, Zimmerman PL; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 285 (abstract no. M.B.P.379).
University of Southern California and the Estelle Doheny Eye Institute, Los Angeles, California, USA
OBJECTIVE: To describe highly characteristic clinical features and light and electron microscopic findings of P. Carinii choroidal infiltrates in three patients with AIDS. METHODS: Three patients were followed antemortem for AIDS-related conditions; two had Cytomegalovirus retinitis treated with ganciclovir. New choroid lesions developed and retinal photographs were obtained. At autopsy, the globes of the eyes were examined grossly, by light microscopy and by electron microscopy. RESULTS: The characteristic fungus changes in P. carinii choroiditis consist of multiple slightly elevated, plaque-like, yellow-white lesions in the choroid. Some of these choroidal lesions are round or oval, while others are geographic or multilobulated in shape. The lesions vary in size and are usually covered by relatively normal retinal pigment epithelium. However, some of the larger lesions may show areas of mild retinal pigment epithelial alteration consisting of fine mottling or granular change. The fundus changes are not associated with introcular inflammation. The etiology of the fundus pathology was determined by electron microscopy demonstrating P. carinii organisms. CONCLUSIONS: P. carinii can produce characteristic funduscopic changes in the choroid and such findings can indicate disseminated P. carinii infection.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Chorioretinitis
- Choroid
- Choroid Diseases
- Choroiditis
- Cytomegalovirus Retinitis
- Eye
- Eye Infections, Fungal
- Eye Infections, Parasitic
- Eye Infections, Viral
- Fundus Oculi
- Ganciclovir
- Humans
- Pigment Epithelium of Eye
- Pneumonia, Pneumocystis
- Retina
Other ID:
UI: 102177233
From Meeting Abstracts