Bouzas MB, Mathov I, Muchinik G, Campestri R, Perez BR, Vercauteren G; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 419 (abstract no. Th.B.P.24).
IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
OBJECTIVE: To study the seroprevalence of HTLV-I antibodies on hemophiliacs. METHODS: Sera previously drawn from 127 hemophiliacs for assessment of HIV-1 incidence (51 -40.2%- HIV-1-pos. and 76 -59.8%- HIV-1-neg.) were studied to determine the impact of HTLV-I. Sera were screened for HTLV-I antibodies by means of an ELISA assay (CPI). Samples repeatedly positive or undeterminated were tested thru Western blot. RESULTS: Only 1 (0.79%) out of 127 was HTLV-I-pos. Western blot showed bands at p24, p36, gp46, p53. A retrospective study of this patient demonstrated seropositiveness as from 1985. No cross-reaction was observed between HIV-1 and HTLV-I. The HTLV-I-positive serum sample was HIV-1-negative. CONCLUSION: No co-infection with HIV-1 and HTLV-I was found. Our data suggest that in our country HTLV-I-infection among hemophiliacs is very low, although more studies should be performed to ascertain the seroprevalence of this virus on the group. (Supported by a grant from Fundacion Roemmers).
Publication Types:
Keywords:
- Argentina
- Blotting, Western
- Cross Reactions
- Enzyme-Linked Immunosorbent Assay
- HIV Infections
- HIV-1
- HTLV-I Antibodies
- HTLV-I Infections
- Hemophilia A
- Human T-lymphotropic virus 1
- Humans
- Incidence
- Retrospective Studies
- Seroepidemiologic Studies
- immunology
Other ID:
UI: 102178040
From Meeting Abstracts