Currie J, Ramsden BM, Lynch JM, McArthur CL, Benson EM, Perdices M; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 464 (abstract no. Th.B.P.290).
Mental Health Research Institute of Victoria, Melbourne, Australia
OBJECTIVES: To determine whether antisaccadic eye movements are of clinical use in detecting the early onset of neurological dysfunction in asymptomatic HIV seropositive (HIV+) subjects. METHODS: We used high resolution infrared oculography and an eye movement test battery that included an antisaccadic paradigm. Subject groups included homosexual HIV seronegative (HIV-) and heterosexual HIV- controls, asymptomatic HIV+ subjects, neurologically intact AIDS patients and patients with cortical or subcortical dementia. RESULTS: In asymptomatic HIV+ subjects, pro-saccades, smooth pursuit and antisaccadic accuracy did not differ significantly from controls. However, antisaccadic latencies were significantly prolonged in 38% of asymptomatic HIV+ subjects (p less than 0.01), suggesting a subtle impairment of frontal lobe ocularmotor programming. CONCLUSIONS: The antisaccadic eye movement paradigm is a valuable, rapid and non-invasive technique for the early detection of neurologic dysfunction in non-demented AIDS patients and in asymptomatic HIV+ subjects. In particular, it may be of use in selecting high risk patients requiring antiviral therapy, in quantitatively monitoring neurologic disease or response to therapy and in providing reassurance to well subjects by helping to differentiate affective disturbance from early dementia.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Dementia
- Eye Abnormalities
- Eye Movements
- HIV Infections
- HIV Seropositivity
- Homosexuality
- Humans
- Movement
- Pursuit, Smooth
- Saccades
- abnormalities
Other ID:
UI: 102178300
From Meeting Abstracts