Sinicco A, Moniaci D, Greco D, Raiteri R, Marietti G; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 473 (abstract no. Th.B.P.344).
University of Turin, Turin, Italy
OBJECTIVE: To determine the salivary SIgA levels during the HIV infection and evaluate their possible role in the control of oral HIV-related lesions (OHRL). METHODS: 93 subjects were studied: 72 AbHIV+ and 21 healthy controls (H.C.). 32 AbHIV+ didn't show OHRL, 25 were affected by oral candidiasis and 15 by hairy leukoplakia (H.L.). SIgA RID-plates, containing a monospecific anti-secretory component antiserum, were used to evaluate SIgA. IgM and IgA immunoprecipitation allowed to exclude that free secretory component and/or SIgM presence could distort our results. Total salivary proteins (T.P.) and albumine were also tested to exclude the phlogosis influence. Mean value for every patient group are reported in the table. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSION: A significant SIgA increase appeared in AbHIV+ compared with H.C. No difference resulted between patients with or without OHRL. The lack of significant difference in the SIgA synthesis shows the minor role of the local humoral response in the control of these lesions. On the contrary, the strict relationship between circulating CD4+ decrease and OHRL emphasized the cell-mediated immune response importance also in the oral cavity.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Candidiasis, Oral
- HIV Infections
- HIV Seropositivity
- Humans
- Immunoglobulin A, Secretory
- Leukoplakia, Hairy
- Mouth Diseases
- Secretory Component
Other ID:
UI: 102178354
From Meeting Abstracts