Diaz C, Jimenez E, Lopez L, Lopez-Correa R, Carrer M, Garcia JM; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 982 (abstract no. W.G.O.2).
The University of Puerto Rico School of Medicine, Puerto Rico, USA
OBJECTIVE: To describe demographic, clinical and outcome features of symptomatic children with perinatal HIV infection. METHODS: Symptomatic children (CDC. Class 2) with perinatal HIV infection were followed from 1984 to 1988. Demographic, clinical and outcome variables were uniformly abstracted in each center. RESULTS: Of 89 symptomatic children (50 boys, 39 girls) 54 (60%) were alive up to December 1988; 8 (10%) had been lost to follow-up. Median age of survivors 46 mo. (range 1-120 mos.) with symptoms related to HIV appearing from 2 wks. to 34 mo. of age. A history of IVDU was present in one, both parents or mother's previous sex partner in 93% of families. Predominant signs and symptoms included hepatosplenomegaly (84%), diffuse adenopathy (76%), lymphoid interstitial pneumonia (38%) and growth failure (65%). Patients who died (27/81=30%: 16 boys, 11 girls) had significantly lower median age at onset of symptoms (12 mo.) and age at diagnosis (9 mo.) than survivors (p less than .01). Mean survival time from diagnosis to death in girls was significantly less than boys (4.6 mos. vs. 9.8, p less than .05). CONCLUSIONS: Children with perinatal HIV infection who died had a lower median age at onset of symptoms; mean survival time from diagnosis to death in girls was less than in boys.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Child
- Female
- HIV Infections
- HIV Seropositivity
- Hospitals, Pediatric
- Hospitals, University
- Hospitals, Urban
- Humans
- Male
- Mothers
- Puerto Rico
- Survival Rate
Other ID:
UI: 102181115
From Meeting Abstracts