Shum A, McGraw T, Vowels B, Gardner M, Hofmann B, Fahey JL; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 188 (abstract no. Th.A.275).
UCLA School of Medicine, Los Angeles, CA, USA
OBJECTIVE: To determine the changes in serum markers of immune activation in lymphoid subsets during the course of SIV infection in rhesus monkeys. METHODS: 2 groups of 4 rhesus macaque monkeys were infected with SIV and tested at approximately monthly intervals for 9 and 18 months. Beta-2 microglobulin (B2M) and neopterin were measured by RIA in serum obtained on the same day as blood for cellular phenotyping by flow cytometry. RESULTS: Neopterin rose markedly at 2 weeks and subsided by 1 month, but remained elevated during SIV infection. Monkeys with higher neopterin levels also had lower CD4 T cell levels. B2M did not rise early in SIV infection but did increase over time. CD4 T cells fell early in infection and showed several patterns of further fall. CD8 T and NK cells varied but did not have a consistent pattern. B cells, however, began to increase after about 5 months and reached levels approximately twice baseline. CONCLUSION: Immune activation in SIV was evident in the serum neopterin increases and later rises in B2M and B cell levels. The correlation between immune activation changes and the course of immune deficiency in SIV infection will be reported.
Publication Types:
Keywords:
- Animals
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Communicable Diseases
- HIV Infections
- Immunologic Deficiency Syndromes
- Infection
- Killer Cells, Natural
- Longitudinal Studies
- Macaca mulatta
- Neopterin
- Simian immunodeficiency virus
- T-Lymphocytes
- beta 2-Microglobulin
Other ID:
UI: 102181830
From Meeting Abstracts