Schiodt M, Atkinson J, Greenspan D, Fox P, Dodd CL, Daniels TE, Hollander H, Chernoff D, Greenspan JS; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 215 (abstract no. Th.B.374).
Oral AIDS Center, University of California, San Francisco, California USA
OBJECTIVE: To compare salivary chemistry of HIV-associated salivary gland disease (HIV-SGD) with that in HIV-seropositive controls and primary Sjogren's syndrome(SS). METHODS: HIV-SGD was defined as the presence of xerostomia or enlarged salivary glands in an HIV infected individual. Stimulated parotid saliva was obtained from seven adult homosexuals with HIV-SGD with enlarged parotid glands, control groups of 13 HIV+ males without SGD and 37 patients with primary SS. Saliva IgA, protein, Na+, K+, C1-, lactoferrin, lysozyme, albumin and IgA rheumatoid factor (IgA RF) were measured. RESULTS: IGA, protein and K+ were significantly increased in HIV-SDG and SS, compared to HIV+ controls. The IgA RF levels in HIV-SGD and HIV+ controls were similar, and lower than in SS. CONCLUSION: HIV-SDG has, like SS, a number of sialochemical differences from normals, but quantitatively these differences are less pronounced than in SS. The increased IgA in parotid saliva of HIV-SDG suggest an active local Ig production in the glands. The pathogenesis of this condition should be further studied.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Adult
- Anti-HIV Agents
- HIV
- HIV Infections
- HIV Seronegativity
- HIV Seropositivity
- Humans
- Male
- Parotid Gland
- Rheumatoid Factor
- Saliva
- Salivary Gland Diseases
- Salivary Glands
- Sjogren's Syndrome
- Xerostomia
- immunology
Other ID:
UI: 102181939
From Meeting Abstracts