Paycha F, Lepretre A, Girard PM, Meulemans A, Russ G, Coulaud JP; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 226 (abstract no. Th.B.417).
Departement de Medecine Nucleaire et des Maladies Infectieuses, INSERM U13, Hopital Bichat-Claude Bernard, Paris, France
OBJECTIVE: To evaluate the comparative efficacy of three nebulizers for lung deposition of pentamidine. METHODS: Pentamidine isethionate (150 mg), mixed with technetium-99m-labeled human serum albumin was administered by means of one jet nebulizer (Respirgard, Marquest) and two ultrasonic nebulizers (DP 100, DP Medical; Portasonic, De Vilbiss) to 8 HIV patients under primary prophylaxis with aerosolized pentamidine. All patients inhaled pentamidine with each nebulizer (one inhalation every two weeks) and the lung edge was previously defined by 20% contour of the chest posterior view on a 99-m Tc-macro-aggregates perfusion scan. Side effects during inhalation were recorded. 4 indexes were determined: Pulmonary uptake/Total body uptake (PF), aerosol penetration index (API) calculated by PIV/PIP where PI = peripheral counts per pixel/inner counts per pixel with PIV measured after inhalation and PIP after perfusion, total pulmonary uptake (TPU), absolute alveolar deposition (AAD) defined by APIxTPU. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. Side effects were minimized with Respirgard, intermediate with Portasonic and pronounced with DP100. CONCLUSIONS: (1) Respirgard was the best tolerated nebulizer with the lowest extrapulmonary deposition. (2) The highest relative peripheral deposition reflected by API was obtained with the Portasonic although the absolute peripheral amount (AAD) was not significantly different. (3) Ultrasonic nebulizers with high potency quartz can achieve high alveolar deposition but are associated with more frequent side effects.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Administration, Inhalation
- Aerosols
- Drug Administration Routes
- Evaluation Studies
- HIV Infections
- Humans
- Lung
- Nebulizers and Vaporizers
- Pentamidine
- methods
- utilization
Other ID:
UI: 102181991
From Meeting Abstracts