Busch H, Riechmann S, Heidenreich S, Heyen P, Zidek W; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 274 (abstract no. M.B.2371).
Department of Internal Medicine, Westfaelische Wilhelms-Universitaet, FRG
As well the AIDS associated nephropathy as the renal location of dissiminated opportunistic infections makes it necessary to have an early non invasive screening for renal complications. In 56 HIV infected patients 24h urine was tested for mikroalbuminuria by nephelometry. The patients were divided up into 4 risk groups: A:hemophilia, B:heterosexuals/transfusions, C:homosexuals, D:intravenous drug users. Although serum creatinine, 24h protein excreation and sonography revealed no sign for renal damage, increased mikroalbuminuria was found in 6 patients. Among these 6 patients we had 4 with mikroalbuminuria greater than 30 mg/1 and a T4-number of less than 100/ul and 2 with T4-number of less than 500/ul. Among the 50 patients with normal mikroalbuminuria less than 20 mg/1 group A patients had a significantly higher level to group B (p=0,05), group C (p=0,004), group D (p=0,06). When comparing urine analysis by nephelometry and Polyacrylamidgel Electrophoresis (PAGE) PAGE indicated in 8 of 27 (29,6%) cases a pathologic result as nephelometry results were still normal. An increased mikroalbuminuria greater than 20 mg/1 can be a sign for AAN long before other pathologic renal results. We believe that nephelometry is more specific than PAGE to indicate the AAN. The relatively increased mikroalbuminuria in group A is a sign for a latent serum illness with a damage of the filtration system. Further investigations will follow.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Creatinine
- Disease Progression
- Glomerular Filtration Rate
- HIV Infections
- HIV Seropositivity
- Hemophilia A
- Homosexuality
- Humans
- Kidney
- Kidney Diseases
- Kidney Function Tests
- Substance Abuse, Intravenous
Other ID:
UI: 102183291
From Meeting Abstracts