Poggio M, Ridolfo AL, Arrigoni L, Gallo L, Rizzi E, Rusconi S, Velati S, Galli M; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 136 (abstract no. W.A.1176).
Transfusional Unit, L.Sacco Hospital, Milan, Italy
OBJECTIVE: To evaluate the modification of serological markers of T cell activation in a group of IVDUs with acute infection or documented seroconversion within 18 months prior to starting the study. METHODS: The study was carried out on 51 IVDUs (21 HIV pos. and 30 HIV neg.) and on 20 healthy controls (HC), age- and sex-matched. Soluble CD4, CD8 and IL-2R were measured using standard ELISA techniques (T cell Sciences, Cambridge, MA). RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. sIL-2R concentration was similar in both IVDU groups, but significantly higher than in HC (p less than 0.0001), sCD4 values were increased in HIV neg. IVDUs (p less than 0.0007) and extremely variable in HIV-1 pos. subjects. sCD8 concentration was significantly higher in pos. IVDUs than in neg. IVDUs and HC (both with p less than 0.0001). sCD8 values were significantly higher in neg. IVDUs than HC (p less than 0.003). CONCLUSION: Both pos. and neg. IVDUs showed an increase of serological markers of T cell activation. The marked increase of sCD8 concentration observed in the pos. IVDUs suggests a strong activation of CD8+ cells in the early phase of the infection.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- Antigens, CD8
- CD8-Positive T-Lymphocytes
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- HIV Infections
- HIV Seropositivity
- HIV-1
- Lymphocyte Activation
- SK&F 106528
- Substance Abuse, Intravenous
- T-Lymphocytes
- immunology
Other ID:
UI: 102192368
From Meeting Abstracts