Mbidde EK, Banura C, Desmond-Hellmann SD, Kizito A, Kazura J, Hellmann NS; International Conference on AIDS.

Int Conf AIDS. 1990 Jun 20-23; 6: 102 (abstract no. S.B.26).

Uganda Cancer Institute (UCI), Kampala, Uganda

An increase in B-cell lymphomas has been noted in young homosexual men with HIV infection in the USA. No systematic studies seeking this association in Africa have been carried out. OBJECTIVE: To describe an association, if any, between childhood Burkitt's lymphoma (BL) and HIV infection in Uganda. METHODS: All children with histologically confirmed diagnoses of BL admitted to the UCI between 10/18/88 and 12/31/89 were eligible. Evaluation included detailed history, physical examination, standard staging procedures, including debulking laparatomy, tissue for histology and/or fine needle aspiration for cytology. Staging was according to schema devised by Ziegler and Magrath. HIV serology was performed using ELISA (Cambridge Bioscience Recombigen). RESULTS: During this 15 month period, 29 children with BL presented to the UCI. Eleven patients were male and 18 female (M:F = 1:1.6), with a median age of 6 years (range 3-17). Seven patients were stage A, none stage AR, 4 stage B, 8 stage C, and 10 stage D. All patients (29/29) were HIV ELISA negative. CONCLUSION: Burkitt's lymphoma, a B-cell lymphoma, is not associated with HIV infection in Ugandan children. This is in contrast to the other major HIV-associated malignancy, Kaposi's sarcoma, which is being observed with increasing frequency at the UCI in HIV-infected children. The explanation for these observations is not clear. The study of relationships between HIV and malignant disease can provide important clues to the interaction among viral infections, host immunity and neoplasms, and deserves further study.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Africa
• Burkitt Lymphoma
• Child
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Lymphoma, Non-Hodgkin
• Male
• Sarcoma, Kaposi
• Serologic Tests
• Uganda

Other ID:

• 30002690

UI: 102195877

From Meeting Abstracts