Poizot-Martin I, Gamby T, Dhiver C, Lafeuillade A, Bouabdallah R, Gastaut JA; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 357 (abstract no. 2014).
C.I.S.I.H. Hopital Salvator, Marseille, France
OBJECTIVE: A study of increased pigmentation in the skin and its appendages is reported. METHODS: Clinical and biologic signs of adrenocortical deficiency (weakness, weight loss, abdominal pain, hypotension, hyponatremia, hypokalemia, hypoglycemia, eosinophilia, negative fluid balance) were investigated and adrenocortical function test was performed. Biopsy specimen of the hyperpigmented areas was taken in one case. Previous medication and/or previous use of nicotine or drugs were evaluated. RESULTS: Five out of 600 HIV-infected patients had skin hyperpigmentation: 4 homosexual males in stage IV with a darkening of the skin of the whole body; One intravenous drug abuser female in stage III with a transverse blue line on the first fingernails and toenails, with also well-defined brown-black macules in the buccal mucosa. None of the patients showed clinical or biological symptoms of adrenal insufficiency and levels of plasma cortisol were normal in all cases. The biopsy specimen showed an increase in epidermal melanin. We consider that these hyperpigmentations were drug-induced. Three patients were treated with pyrimethamine (50 mg/day for 3 months, 75 mg/day for 1 year, 100 mg/day for 1 month), one with ketoconazole (800 mg/day for 1 month). The nails' pigmentation was related to azidothymidine (800 mg/day for 1 year) and the oral mucosa pigmentation to nicotine. CONCLUSION: Physicians prescribing these treatments need to be aware in order to avoid unnecessary or prolonged administration of corticosteroids.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Female
- HIV Seropositivity
- Humans
- Hyperpigmentation
- Integumentary System
- Male
- Melanins
- Mouth Diseases
- Mouth Mucosa
- Skin
- Skin Pigmentation
- Zidovudine
- organization & administration
Other ID:
UI: 102197022
From Meeting Abstracts