Reddy S, Policar M, Masci J, Shimshi M; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B228 (abstract no. PoB 3822).
Elmhurst Hospital Center, New York City.
ISSUE/PROBLEM: The diagnosis of isolated hypoaldosteronism may be overlooked in patients with HIV infection. DESCRIPTION OF PROJECT: At our institution, we have identified 2 cases of hypoaldosteronism with normal serum cortisol and cotrosyn stimulation tests in HIV-infected patients. Patient #1 complained only of weakness and fatigue. His blood pressure was low normal, and he was hyperkalemic on only 1 occasion. Patient #2 presented with vomiting, orthostatic hypotension and hyperkalemia. RESULTS: Patient #1 had a low aldosterone level in the face of an elevated renin level. Patient #2 had undetectable aldosterone levels in both the upright and recumbent positions. Both patients had a normal response to cosyntropin testing. The symptoms of both patients resolved with Florinef administration. Patient #2 later developed hypocortisolism and was placed on steroids. LESSONS LEARNED: The presentation of isolated hypoaldosteronism in HIV-infected patients may be subtle, and can progress to complete hypoadrenalism.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adrenal Insufficiency
- Aldosterone
- Aldosterone Synthase
- Blood Pressure
- Fludrocortisone
- HIV Seropositivity
- Humans
- Hydrocortisone
- Hyperkalemia
- Hypoaldosteronism
- Renin
- Renin-Angiotensin System
- diagnosis
- fludrocortisone 21-acetate
Other ID:
UI: 102199268
From Meeting Abstracts