elSakr M, Ahuja J, Lake-Bakaar G; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: 76 (abstract no. PuB 7164).
VAMC Northport, NY.
OBJECTIVES: Human gastric parietal cells secrete both intrinsic factor IF and gastric acid. We sought to determine whether IF secretion correlates with reduced acid secretion in subjects infected with HIV. METHODS: The study group comprised 8 male subjects: healthy volunteer controls (n = 3); HIV positive subjects without AIDS (n = 3) and patients with AIDS (n = 2). The risk factors for HIV disease were intravenous drug abuse or homosexuality. CD4 counts were below 500 in all HIV infected subjects. Gastric juice pH and free acid were determined in juice collected after an overnight fast and maximal acid output (MAO) measured after pentagastrin injection. IF was measured using a cobinamide blocking assay. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. SUMMARY: i. Reduced fasting gastric acid secretion and increased pH occurs early in HIV infection. ii. Pentagastrin stimulated intrinsic factor and acid secretion are reduced in patients with AIDS. iii. Fasting gastric juice pH correlates closely with fasting IF concentration (r = 0.74; p = 0.06) in HIV disease iv. Pentagastrin stimulated acid secretion (MAO) correlates well with IF secretion (r = 0.8; p = 0.03) in HIV disease. CONCLUSION: These data suggest global parietal cell dysfunction or destruction in AIDS.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Gastric Acid
- Gastric Juice
- HIV Infections
- HIV Seropositivity
- Humans
- Intrinsic Factor
- Male
- Parietal Cells, Gastric
- Pentagastrin
- secretion
Other ID:
UI: 102202163
From Meeting Abstracts