Munema FM, Mbena E; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 324 (abstract no. PO-B07-1130).
Department of Medicine, Muhimbili Medical Centre, Dar es Salaam, Tanzania.
In order to substantiate the main causes of anti-tuberculosis drug toxicity, adverse reactions and Stevens-Johnson Syndrome, was done, analysis of all the investigations results of 100 patients who had reacted and developed S.J. Syndrome during the course of treatment for pulmonary tuberculosis. Analysed were results of Sputum-AFB-Culture/sensitivity, Blood for HIV antibodies-ELISA/WESTERN BLOT; Blood/Slide for Malaria Parasites, *VDRL and TPHA, pyogenic/enteric culture/sensitivity; stool-for worms/ova and Urine for parasites and culture for microbial growth/sensitivity. Pulmonary tuberculosis had been established on chest Xray and sputum-direct smear for AFB results. Treatment given comprised of Streptomycin sulphate injections i.m. (isoniazid +/- Rifampicin) Rimactazid/Rifinah tablets; pyrazinamide and Ethambutol or Thiazina (Thiacetazone +/- Isoniazid). Majority who reacted, 62/100, reacted to Thiazina tabs. These were reported seropositive-for HIV-on ELISA/WESTERN BLOT. Other causes were Malaria infection, worm infestations, resistance of bacilli to isoniazid or other drugs, over/wrong dosage and lues,? expired drugs. Severe reactions occasionally ended fatally in two cases with AIDS. All the anti-tuberculosis drugs used caused adverse reactions but majority of the adverse effects were caused by Thiacetazone or another sulphur containing drugs used in combination. Prompt and appropriate use of anti histamines, steroids and symptomatically proven other antibiotics cured/improved the patients.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Developing Countries
- Drug Toxicity
- Ethambutol
- HIV Infections
- HIV Seropositivity
- Humans
- Isoniazid
- Pyrazinamide
- Rifampin
- Sputum
- Streptomycin
- TB 450
- Thioacetazone
- Tuberculosis
- Tuberculosis, Pulmonary
- methods
Other ID:
UI: 102204030
From Meeting Abstracts