Ponge-Wilson I, Moy J, Rosenthal S, Sanchez M; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 363 (abstract no. PO-B09-1367).
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, NY 10016.
The severe immunosuppression associated with HIV infection increases susceptibility to opportunistic fungi. Among approximately 2200 patients with AIDS admitted to our hospital over the past 7 years, only one, an intravenous drug user with gangrenous cellulitis due to Rhizopus arrhizus was diagnosed with zygomycosis. Through review of the medical literature, we identified nine additional cases of zygomycosis associated with HIV infection. Eight of ten cases occurred in persons with active use of intravenous narcotics, which is a well known risk factor for zygomycosis independently of immunodeficiency. One of the two cases occurring in gay men without intravenous drug use was neutropenic from drugs. Four cases were rhinocerebral, 4 cutaneous, one renal and one oral. Isolated organisms from cultured tissue were Rhizopus arrhizus (3), Absidia corynbifera (3) and Cunninghamella bertholletiae (1). Three of the eight HIV infected intravenous drug users had necrotic cellulitis in areas used for injection. Sixty percent of patients recovered with treatment. HIV-induced immunosuppression does not appear to be a significant predisposing factor for infection with zygomycotic fungi.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Cunninghamella
- HIV Infections
- HIV Seropositivity
- Homosexuality
- Humans
- Male
- Rhizopus
- Risk Factors
- Substance Abuse, Intravenous
- Zygomycosis
Other ID:
UI: 102204286
From Meeting Abstracts