Policar M, Shimshi M, Masci J; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 464 (abstract no. PO-B25-1973).
Dept. of Medicine Elmhurst Hospital Center, New York.
Five HIV-infected patients with hypoaldosteronism and normal serum cortisol and corticotropin testing have been identified at our institution. All patients presented with weakness and fatigue. Four patients had orthostatic hypotension, and the fifth had a low normal blood pressure. Two patients were persistently hyperkalemic, two only sporadically so, and one was normokalemic. Hyponatremia was a constant finding. One patient had a low aldosterone level in the face of an elevated renin level. The remainder of the patients had undetectable aldosterone levels in both the upright and recumbant positions. In all patients, corticotropin testing failed to stimulate aldosterone secretion. All patients showed clinical and chemical response to fludrocortisone. Although they remained clinically well, repeated corticotropin testing revealed progression to glucocorticoid deficiency in two patients. In our experience, the presentation of isolated hypoaldosteronism in HIV-infected patients may be subtle, and can progress to complete hypoadrenalism.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Adrenocorticotropic Hormone
- Aldosterone
- Aldosterone Synthase
- Asthenia
- Disease Progression
- Fatigue
- Fludrocortisone
- HIV Seropositivity
- Humans
- Hydrocortisone
- Hypoaldosteronism
- Hyponatremia
- Paresis
- Renin
- Renin-Angiotensin System
Other ID:
UI: 102204952
From Meeting Abstracts