Ayers MM, Turnbull V, Siregar H, Crowe SM, Gonzales MF; Australasian Society for HIV Medicine. Conference.
Annu Conf Australas Soc HIV Med. 1993 Oct 28-30; 5: 99 (poster no. 48).
Neuropathology Research Laboratory, Royal Melbourne Hospital, Parkville, Vic.
Attention has recently focussed on Schwann cells as antigen presenting cells in inflammatory demyelinating polyneuropathy (IDPN). Whether Schwann cells process and present antigen following viral infection is of particular interest. To determine if human Schwann cells can be infected by HIV, cultures of Schwann cells were established from a sural nerve biopsy in a patient with Type 1 hereditary motor sensory neuropathy (HMSN). Three cultures were established over a period of eight weeks. Two cultures were then exposed to the Ba-L strain of HIV. HIV p24 was quantified in all three culture supernatants by ELISA and cultures double immunostained for p24 and the Schwann cell marker, S-100 protein. The data from these experiments are preliminary but indicate that Schwann cells can be infected in vitro by HIV. Infection of Schwann cells by HIV may be an important event in the pathogenesis of HIV-associated peripheral neuropathy.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Biomedical Research
- Culture
- HIV
- HIV Antibodies
- HIV Antigens
- HIV Core Protein p24
- HIV Envelope Protein gp120
- HIV Infections
- HIV Seropositivity
- Humans
- In Vitro
- Peripheral Nervous System Diseases
- Polyneuropathies
- Schwann Cells
- immunology
- pathogenicity
Other ID:
UI: 102208064
From Meeting Abstracts