Uchida T; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 178 (abstract no. PB0139).
Takamatsu Red Cross Hospital, Japan.
OBJECTIVE: A case of signet cell cancer associated with AIDS is presented. CASE HISTORY: A 50-year-old Japanese man with hemophilia A had required multiple injections of factor VIII concentrate since 1973. He developed dysphagia, heartburn and hiccups on July 1987. He lost 10kg in weight during 2 months. No lymph-node swelling or Kaposi's sarcoma was found. An upper GI series showed an obstruction in the esophageal region. The biopsy showed signet cell carcinoma. In addition to gastric cancer, an esophageal candidiasis was also observed in an endoscopic examination. HIV antibody was positive in gp160, 120, 41, p55, 32, 24, 18 by WB. The HIV antigen was negative. Twenty days after his admission, febrile condition reached a continuous 40C. Cultures of blood grew candida species. CD4 lymphocytes decreased by less than 400/ul since the end of October. His massive hemorrhage from the gastric cancer continued and he died on November 24, 1987. DISCUSSION AND CONCLUSIONS: Signet cell carcinoma is not one of the cancers typically seen in AIDS. It is possible that the patient had a coincidental carcinoma along with AIDS. It is suggested, however, that the HIV infection had a role in causing the signet cell carcinoma, giving rise to its classification as an opportunistic tumor.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Animals
- Biopsy
- Carcinoma
- Carcinoma, Signet Ring Cell
- Carcinoma, Squamous Cell
- Gizzard
- Hemophilia A
- Humans
- Male
- Sarcoma, Kaposi
- Stomach
- Stomach Neoplasms
Other ID:
UI: 102208409
From Meeting Abstracts