Duerr A, Xia Z, Nagachinta T, Tovanabutra S, Tansuhaj A, Nelson K; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 33 (abstract no. 105C).
Centers for Disease Control, Atlanta.
OBJECTIVE: To investigate the dynamics of heterosexual HIV transmission after repeated exposure to a single HIV+ partner in northern Thailand. METHODS: HIV-positive (HIV+) male blood donors and their regular female sex partners were interviewed separately about sexual practice (type & frequency of intercourse), contraceptive use and sexually transmitted disease (STD). Assessment included physical examination, STD cultures & serologies, HIV (ELISA, WB & subtyping), and CD4 count. Women with HIV risk factors other than sexual exposure to an index male were excluded. RESULTS: Between 3/92 and 11/93 250 HIV+ men and their wives (or regular girlfriends) were enrolled. 108 (43%) women were HIV+. In a subsample of 34 newly-married couples, the total number of at-risk sex acts could be calculated as it was determined that the male was HIV+ prior to sexual contact with the wife. 9/34 (26%) women were HIV+; the probability of HIV transmission was 1.6 [0.6-2.6] per 1000 sexual contacts (vaginal). All HIV isolates were subtype (clade) E. Transmission was more likely when the wife gave a history of an STD (OR = 19.2, p = .01) or the CD4 count of the male was < 200 (OR = 4.5, p = .14). Very little condom use was reported; no effect of anal intercourse, sex during menstruation, +STD culture or oral contraceptive use was seen. CONCLUSION: The probability of heterosexual HIV (subtype E) transmission in Thai couples, while much lower than recent estimates of transmission from Thai prostitutes, does not differ significantly from that seen among European and American couples. Models of the effect of repeated sexual exposure will be presented.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Blood Donors
- CD4 Lymphocyte Count
- Coitus
- Contraception
- Contraceptive Agents
- Disease Transmission, Horizontal
- Female
- HIV
- HIV Infections
- HIV Seronegativity
- HIV Seropositivity
- Humans
- Male
- Probability
- Risk Factors
- Sexual Partners
- Sexually Transmitted Diseases
- Thailand
- immunology
- transmission
Other ID:
UI: 102209081
From Meeting Abstracts