Lima JN, Almeida EA, Aoki FH, Torres-Morales AE, Giraldo LE, Abreu WB, Monteiro DT; International Conference on AIDS.

Int Conf AIDS. 1994 Aug 7-12; 10: 159 (abstract no. PB0649).

State University of Campinas, UNICAMP, SP, Brazil.

OBJECTIVE: to verify the frequency of the co-infection HIV-Chagas at the AIDS out patient departament (HC/UNICAMP-Campinas, SP), the clinical presentation, therapy and the follow-up of the patients with both infections. METHODS: to perform the serology for Chagas' disease (Complement Fixation and Immunofluorescence-Clin. Pathol. Labor./UNICAMP) in 225 patients infected by HIV-1; it was analysed: diagnoses, classification of the clinical forms of the disease, therapy, xenodiagnosis and clinical evolution. RESULTS: the concomitance of both infections occured in 7 cases (3.1%), 5 cases were asymptomatic infections of HIV-1 and 2 cases showed symptomatic AIDS; the average age is 48.3 +/- 7.8 (36 to 61 years of age) and 3 were female. The Chagas' disease (CD) transmission was vectorial and all are found in the indeterminate form of the disease. The xenodiagnosis was positive only in one case with AIDS-disease, demonstrating high parasitemy of Trypanosoma cruzi; this patient was treated with ketoconazole (400 mg/dayly/30 days) by candidiasis and had the maintenance therapy (200 mg/dayly/8 months) by observation of the xenodiagnosis becoming negative. Regarding the HIV, the clinical follow up was an average of 29.5 +/- 16.0 months, and there was no modifications of the clinical forms in both illnesses. DISCUSSION AND CONCLUSIONS: 1. although preliminaries the findings demonstrate high frequency of the concomitance of the diseases, considering that the area of study is not endemic for CD. 2. probably the immunedeficiency by HIV-1 contributed for the rise of the parasitemy by T. cruzi, modifying the natural evolution of CD. 3. the treatment of candidiasis with ketoconazole was also efficient, reducing the parasitemy by T. cruzi, and in this manner can be considered one more option for the ethiologic treatment of CD.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Animals
• Chagas Disease
• Communicable Diseases
• Female
• HIV Infections
• HIV Seropositivity
• HIV-1
• Humans
• Trypanosoma cruzi
• Xenodiagnosis
• psychology
• therapy

Other ID:

• 94371253

UI: 102210083

From Meeting Abstracts