Harris P, Curry R; International Conference on AIDS.

Int Conf AIDS. 1994 Aug 7-12; 10: 196 (abstract no. PB0797).

AIDS Clinical Research Center of Washington, DC 20009.

OBJECTIVE: Ten of 200 patients have complained over the last year of polyuria, polydipsia and nocturia. We were interested in whether diabetes insipidus (DI) may be directly associated with this infection. METHODS: We measured urine and serum osmolalities, serum antidiuretic hormone (ADH), serum sodium, BUN, glucose and potassium levels; calculated serum osmolalities; evaluated CD4 and CD8 counts, Beta-2 microglobulin and HIV P-24 antigen levels; assessed recent brain scans; reviewed clinical pictures and noted current medications. RESULTS: ADH levels were less than 1 pg/ml, serum osmolalities 295-312 mos/kg H2O, CD4 levels 3-564/cmm, CD8 levels 86-1186/cmm, Beta-2 microglobulin levels 3.5-5.6 mg/l. Five had reactive HIV P-24 antigens. Seven had essentially normal MRI's (3 not done). Medication and secondary infection did not account for DI. DISCUSSION AND CONCLUSIONS: That 5% of our patients have primary central diabetes insipidus suggests DI may be an underestimated complication of HIV infection.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antigens, CD4
• Arginine Vasopressin
• Diabetes Insipidus
• Diabetes Insipidus, Neurogenic
• HIV Antigens
• HIV Infections
• Humans
• Polyuria
• Vasopressins
• beta 2-Microglobulin
• immunology
• organization & administration

Other ID:

• 94371417

UI: 102210250

From Meeting Abstracts