Adelman AG, Cohen EA; International Society of Technology Assessment in Health Care. Meeting.
Abstr Int Soc Technol Assess Health Care Meet. 1992; 29.
Toronto and Mount Sinai Hospital, University of Toronto, Cardiology, Ontario, Canada.
Percutaneous transluminal coronary angioplasty (PTCA) is an established method of treating coronary artery narrowing (stenoses) without the need for surgery. In over 90% of cases angioplasty is successful in opening the artery. However, in 40% of cases the artery renarrows in the first six months. The Simpson Directional Atherectomy Catheter (DCA) is a new surgical method for debulking rather than reshaping the atherosclerotic plaque which obstructs the vessels. A small metal housing at the end of DCA catheter is positioned across the stenosis using standard angioplasty technique. This device contains a tiny cup shaped cutter that is rotated rapidly and advanced through the plaque shaving minute slices that are compacted into a collection chamber in the nose of the cone. Preliminary data suggests that the restenosis rate may be lower for the DCA procedure. The Canadian Coronary Atherectomy Trial, funded by the Medical Research Council of Canada, is designed to compare DCA to PTCA to determine if this is true. This multi-centre, prospective, randomized, controlled study is currently being carried out across Canada. Restenosis will be assessed blindly from procedural and six month follow-up angiograms using a computerized, quantitative, coronary analysis system and a well tested objective angiographic protocol. If this trial confirms a lower restenosis rate with DCA, then an important clinical problem will have been at least partially solved. This presentation will provide the basis for discussion of trial design in the evaluation of clinical technology.
Publication Types:
Keywords:
- Angioplasty, Transluminal, Percutaneous Coronary
- Atherectomy, Coronary
- Canada
- Clinical Trials as Topic
- Coronary Vessels
- Evaluation Studies
- Follow-Up Studies
- Longitudinal Studies
- Prospective Studies
- surgery
- hsrmtgs
Other ID:
UI: 102211910
From Meeting Abstracts