Eyre DR, Gertz BJ, Shao P, Hanson DA, Harris ST, Genant HK, Chesnut CH.

J Bone Miner Res. 1992 Aug; 7: S143.

Univ. of Washington, Seattle.

An immunoassay for monitoring bone resorption that detects cross-linked N-telopeptides of type I collagen (J. Bone Miner. Res. 6: S251, 1991; Ostex Inc., Seattle, WA) was applied to urine samples collected from 65 early post-menopausal (>6 mo. to 3 yr) women in a placebo-controlled longitudinal trial of the bisphosphonate, alendronate. Results on eight serial samples collected over 9 mo. were compared with data on other markers of bone metabolism and spinal bone mineral density changes assessed by DEXA. Substantial differences were seen between subjects in their baseline bone resorption rates based on urinary excretion of the cross-linked peptides. In the placebo group, for example, the mean over 9 mo. for individuals ranged from 38 +/- 7 (SD for 8 longitudinal measurements) to 135 +/- 17 pMoles Bone Collagen Equivalents (BCE) per micromole creatinine with an impressive longitudinal consistency for individuals. The greatest decreases in bone density by DEXA tended to be associated with the highest resorption rates biochemically. Alendronate taken for 6 wk at one of three doses (5, 20, or 40 mg/day) suppressed bone resorption by 29 +/- 22 SD (15), 56 +/- 19 SD (14) and 64 +/- 13 SD (15) percent respectively based on the immunoassay measurements after 6 wk of therapy relative to baseline. Plotting longitudinal measurements for individual subjects clearly could detect and quantify a rebound in bone resorption post-therapy that varied dependent on the individual subject and the drug dosage. Levels of urinary pyridinoline and hydroxyproline showed greater variability and appeared less reliable as longitudinal monitors of baseline bone resorption and the responsiveness to therapy of individual subjects.

Publication Types:

• Meeting Abstracts

Keywords:

• Alendronate
• Amino Acids
• Biological Markers
• Bone Density
• Bone Resorption
• Bone and Bones
• Collagen
• Collagen Type I
• Diphosphonates
• Female
• Humans
• Hydroxyproline
• Menopause
• Peptides
• pyridinoline
• NASA Discipline Musculoskeletal
• NASA Discipline Number 26-10
• NASA Program Space Physiology and Countermeasures
• Non-NASA Center

Other ID:

• 95607579

UI: 102212556

From Meeting Abstracts